Photocarcinogenesis and Influence of UV Radiation on Autoimmune Disease in NZB/N Mice234

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Abstract
Several biologic effects of UV radiation on NZB/N mice were studied. NZB mice exhibited normal susceptibility to photocarcinogenesis compared to another pigmented but nonautoimmune mouse strain, C57BL/6NCr. Susceptibility was compared on the basis of latency, anatomic location, and histologic type of tumors induced by chronic UV irradiation. The influence of UV irradiation on progression of spontaneous autoimmune disease in NZB mice was examined with respect to anti-DNA antibodies, excretion of protein in urine, survival, glomerulo-nephritis, and leukemia. UV irradiation of NZB mice reduced both survival of mice and the level of serum antibody binding to DNA. Reduced survival occurred not only in autoimmune mice but also in C57BL/6 mice. Serum antibody binding to single-stranded DNA (ssDNA) was reduced in UV-irradiated NZB mice compared to that in untreated NZB mice, but it recovered to normal (untreated) levels after termination of UV irradiation. No alteration in preference of DNA antibodies for ssDNA, UVssDNA, doublestranded DNA (dsDNA), or UVdsDNA was observed in UV-irradiated mice.