Psychiatric Illness Among Paternal and Maternal Relatives of Poor Prognosis Schizophrenics

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Abstract
In 1966 Slater proposed a computational model for distinguishing polygenic inheritance and the effects of a single dominant gene. For a single dominant gene with diminished penetrance, affected relatives should be found predominantly on either maternal or paternal sides. He further proposed that to support a dominant gene hypothesis the ratio of unilaterally ill pairs to bilaterally ill pairs of relatives should exceed 2:1. ‘Unilateral pairs' means that there have been two or more ill relatives on either paternal or maternal sides; ‘bilateral pairs' that there has been at least one ill relative on each side.