The manifold activity of testosterone dipropionate as compared with that of testosterone propionate in gonadectomized rats

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Abstract
In gonadectomized [male] and [female] rats the manifold effects of testosterone dipropionate are in general similar to those of testosterone propionate, with, however, some important differences. The effect of small doses of the dipropionate on [male] sex organs is weaker (e.g. on the prostate, by about 1.5 times) than that of similar doses of the propionate. With larger doses this difference is much less. In contrast to the propionate, however, the effect of the dipropionate on the [male] sex organs is maintained (completely with 500 g., partially with 150 g.) for at least 10 days after the last inj. Testosterone dipropionate alone, without previous stimulation with oestro-gens, can produce progestational changes in the uterus and vagina, much more similar to those found during pregnancy than the changes produced by the propionate. After the cessation of the inj. (small doses) the development of the vagina is maintained much better than that of the uterus. Testosterone dipropionate has very pronounced bisexual properties (including strong stimulation of the [female] prostate and clitoris) but, from a comparison of its "[male]" and "[female]" activities, it can be classified as a "bisexual hormone possessing chiefly [male] properties." Testosterone dipropionate, in the dose used, did not prevent the metaplastic changes produced in the uterine epithelium by oestradiol dipropionate. Testosterone dipropionate influenced the thymus, adrenals, liver, kidneys, heart, fat deposition and gain in body weight in both sexes, but in most cases, with the doses used, the effects in [female][female] were less pronounced and less constant than in [male][male]. Testosterone dipropionate and oestradiol dipropionate show both co-operative and antagonistic activities on sexual and non-sexual organs.