Discovering differential activation machinery of the Toll-like receptor 4 signaling pathways in MyD88 knockouts
- 26 January 2006
- journal article
- Published by Wiley in FEBS Letters
- Vol. 580 (5) , 1457-1464
- https://doi.org/10.1016/j.febslet.2006.01.046
Abstract
To understand differential time activation of nuclear factor κB (NF-κB) and the temporal features of the downstream pro-inflammatory cytokines’ [tumour-necrosis-factor-α (TNF-α) and IP-10] mRNA levels in myeloid differentiation primary-response protein 88 (MyD88) knockouts (KOs), I developed a computational model of the TLR4 pathway. The result suggests that the late phase expression of NF-κB activity observed in MyD88 KOs is possibly due to a number of novel intermediates acting along the MyD88-independent pathway. I also simulate that the TNF-α levels will increase at a longer time in MyD88 KOs, not previously mentionedKeywords
This publication has 15 references indexed in Scilit:
- Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6Nature, 2005
- Achieving Stability of Lipopolysaccharide-Induced NF-κB ActivationScience, 2005
- Toll-Like Receptor 8-Mediated Reversal of CD4 + Regulatory T Cell FunctionScience, 2005
- Structure–activity relationship of alginate oligosaccharides in the induction of cytokine production from RAW264.7 cellsPublished by Wiley ,2005
- Nod2 Mutation in Crohn's Disease Potentiates NF-κB Activity and IL-1ß ProcessingScience, 2005
- The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascadesPhysiological Genomics, 2004
- Transcriptional activation induced in macrophages by Toll‐like receptor (TLR) ligands: from expression profiling to a model of TLR signalingEuropean Journal of Immunology, 2004
- Toll-like receptor signallingNature Reviews Immunology, 2004
- Toll signaling: RIPping off the TNF pathway.Nature Immunology, 2004
- Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling PathwayScience, 2003