Effects of Amiloride on Arterial Pressure and Renal Function

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Abstract
Amiloride was administered to 13 male patients with mild essential hypertension and normal renal function. It effectively reduced supine and standing arterial pressures. The antihypertensive response was associated with a significant decrease in renal inulin clearance and a rise in plasma creatinine concentration, although both values at the end of 7 wk of therapy remained within normal limits. Serum K concentrations rose but did not reach hyperkalemic levels. Amiloride did not increase blood levels of glucose, uric acid, lipids, Ca, or urea N. Amiloride is an effective antihypertensive and antikaliuretic agent for patients with mild hypertension and normal renal function.