Animal Responses to 2-Deoxy-D-Glucose Administration

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Abstract
The response of mice, rats and rabbits to acute and chronic administration of 2-deoxyglucose (2-DG) has been studied. 1. Mice and rabbits were given large doses of 2-DG intravenously and had symptoms similar to those during insulin hypoglycemia. It is suggested that the symptoms were the result of a cellular glucopenia secondary to inhibition by 2-DG of glucose utilization. 2. Rats receiving 2-DG chronically by subcutaneous administration had elevated blood glucose concentrations and weight loss. On discontinuation of 2-DG administration blood glucose concentrations returned to control values. 3. Rabbits following intravenous or oral administration of small doses of 2-DG had a rapid rise in blood glucose concentrations. The glucose concentrations remained elevated for at least 5 hours. In glucose tolerance tests done shortly after 2-DG administration glucose concentrations decreased more slowly than in control tolerance tests, but the animals did respond to insulin administrations.

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