Demonstration of Histamine Receptors on Human Platelets by Flow Cytometry
- 1 February 1984
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Haematology
- Vol. 32 (2) , 113-118
- https://doi.org/10.1111/j.1600-0609.1984.tb02165.x
Abstract
Fluoresceinated human albumin conjugated with histamine (FHA-HIS) was used for the demonstration of histamine receptors on human platelets. Such receptors were demonstrated on 40-63% of peripheral blood platelets in 4 healthy donors. The binding of FHA-HIS was inhibited on 35-79% of the platelets by the histamine H1 receptor antagonists diphenhydramine and clemastine. The histamine H2 receptor antagonist cimetidine blocked the FHA-HIS binding on 14-37% of the platelets. Histamine H1 as well as H2 receptors occur on human platelets but the receptors are not equally distributed in the platelet population.Keywords
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