A New Approach to Ureteral Exteriorization for Bilateral Renal Studies

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Abstract
A procedure for the transplantation of one or both ureters to a skin-flap in the area of the flank in the dog is described. By this method of unilateral or bilateral skin-flap ureteral exteriorization a chronic preparation satisfactory for the simultaneous collection of urine from the 2 kidneys facilitates the differential study of renal physiology. Renal clearance determination on prepared animals indicated a normal bilateral renal function. Catheterizing the exteriorized ureter was demonstrated to produce ipsilateral reflex redn. in GFR and RPF which may be eliminated in skin-flap exteriorizations by a non-catheterization form of urine collection. Advantages in this preparation over the standard abdominal ureteral exteriorization are: (a) catheterization of the ureter is unnecessary for urine collection; (b) urine may be collected with the animal in any desired position, especially standing; (c) skin excoriation due to urine irritation is completely eliminated; (d) ascending renal infection is minimized; and, only clean quarters are required to maintain complete and lasting integrity of the preparation.

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