Temperature Gradient Method for Continuous Countercurrent Gas–Liquid Chromatography

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Abstract
Continuous countercurrent gas–liquid chromatography (CCGLC), where the gas and liquid phases move countercurrently and the sample can be introduced continuously, is a method suitable for separating binary sample systems. The flow ratio of the gas and liquid phases (G/L) in CCGLC should be between the partition coefficients of the two components to be separated. However, the larger the difference between the G/L and the partition coefficient of one component, the higher the separation efficiency of the other component. By shifting the partition coefficients from the point of introduction of the sample to the directions of the gas and liquid flows, we believed a more efficient separation of the components would be achieved. A separation tower with a temperature gradient was constructed to create an inclined arrangement of the partition coefficient. With this system, the separation of stereoisomers was investigated, and 99.9% purity of trans-decahydronaphthalene was achieved.

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