The immunosuppressive effects of Trichothecenes and Cyclochlorotine on the antibody responses in guinea pigs.

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Abstract
Immunosuppressive effects of trichothecenes from Fusarium solani and F. nivale, T-2 toxin and fusarenon-X, and also of a mycotoxin of Penicillium islandicum, cyclochlorotine, were studied by measuring the anti-2,4-dinitrophenyl (DNP) antibody responses in guinea pigs immunized with DNP-bovine serum albumin. Among these mycotoxins, T-2 toxin alone strongly suppressed the anti-DNP antibody responses at a certain sublethal dose. With other mycotoxins, no effect was observed at any sublethal doses tested. All of the mucotoxins inhibited the in vitro blast transformation of guinea pig splenic cells stimulated with lipopolysaccharide of Escherichia coli (B cell mitogen) or concanavalin A (T cell mitogen), when measured by incorporation of 3H-thymidine into DNA. Their inhibitory activities were independent of the sort of mitogen used. As in the case of the antibody responses, T-2 toxin was most potent in reducing DNA synthesis, and exhibited .apprx. 10 and 1000 times as potent inhibitory activity as fusarenon-X and cyclochlorotine, respectively.