Pharmacological Studies of Lycorenine, an Alkaloid of Lycoris Radiata Herb.: II. Effects of Blood Pressure in Rats and Dogs and the Mechanism of Tachyphylaxis to the Vasodepressor Action of Lycorenine in Rats

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Abstract
Effects were determined of nonspecific smooth muscle relaxants.sbd.papaverine (10-4 M) and aspaminol (1,1-diphenyl-3-piperidinobutanol hydrochloride, 10-4 M).sbd.and Ca-blocker, D-600 [methoxyverapamil] (10-6 M) on Ca-release and Ca-binding in the microsomal fractions of rabbit tenia coli. The doses necessary to relax the K-depolarized tenia coli maximally were used. Ca-binding in the microsomal fractions was inhibited by aspaminol and D-600, and increased by papaverine in the concentration used. Ca-release from the Ca-incorporated microsomal fractions was inhibited by papaverine and aspaminol, but was not influenced by D-600. Changes observed in Ca-transfer may be related to relaxation of smooth muscle induced by the test drugs.