Reciprocal Regulation Between TOC1 and LHY / CCA1 Within the Arabidopsis Circadian Clock
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- 3 August 2001
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 293 (5531) , 880-883
- https://doi.org/10.1126/science.1061320
Abstract
The interactive regulation between clock genes is central for oscillator function. Here, we show interactions between theArabidopsis clock genes LATE ELONGATED HYPOCOTYL(LHY), CIRCADIAN CLOCK ASSOCIATED 1(CCA1), and TIMING OF CAB EXPRESSION 1(TOC1). The MYB transcription factors LHY and CCA1 negatively regulate TOC1 expression. We show that both proteins bind to a region in the TOC1 promoter that is critical for its clock regulation. Conversely, TOC1 appears to participate in the positive regulation of LHY andCCA1 expression. Our results indicate that these interactions form a loop critical for clock function inArabidopsis.Keywords
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