The composition of the liver lipids of sheep and the effect of early sporidesmin poisoning

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Abstract
The liver lipids of normal sheep and of sheep dosed with sporidesmin were isolated quantitatively by a 3-column-chromatography procedure involving a DEAE-cellulose column, a silicic acid-silicate-water column and a silicic acid column. The isolated lipids were identified by infrared spectrometry and paper chromatography, supplemented by chemical analyses. The liver tri-glyceride concentrations rose very significantly (P < 0. 001) in the sporidesmin-poisoned sheep. No changes were observed in the concentrations of other liver lipids. The early effect of the heptatoxin-like action of sporidesmin on sheep was interpreted as a malfunction of a hepatic triglyceride-secreting mechanism.