The Effect of Dietary Phosphorus on the Metabolism of Calcium and Strontium in the Rat

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Abstract
An investigation was made of the way in which changes in dietary P within the physiological range influence the comparative metabolism of Ca and Sr in the rat. Radioactive Ca and Sr were used as tracers. The absorption of both Ca and Sr after oral administration was dependent on the P level in the diet, but not to the same degree. The skeletal ratio Sr85/Ca47 decreased by some 40% as the dietary P was increased from 0.5 to 1.3 g%. After intraperitoneal injection of radioactive Ca and Sr, the skeletal retention of Sr85 was about 25% more on a diet containing 1.3% P than on a diet containing 0.5% P. Skeletal retention of Ca varied little. It is concluded that renal discrimination against Sr and intestinal absorption of Ca and Sr were affected by the P content of the diet, but in opposite directions.

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