Carcinogenic antioxidants
- 11 October 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 332 (1-2) , 159-163
- https://doi.org/10.1016/0014-5793(93)80504-n
Abstract
The synthetic oestrogens diethylstilboestrol, hexoestrol and 17 α-ethynyloestradiol are known to be carcinogenic, yet they all exert antioxidant properties in vitro in that they are good inhibitors of iron ion-dependent lipid peroxidation. In rat liver microsomes incubated with Fe(III)-ascorbate or Fe(III)-ADP/NADPH and also in ox-brain phospholipid liposomes incubated with Fe(III)-ascorbate; the overall order of effectiveness of the compounds tested as inhibitors of lipid peroxidation was diethylstilboestrol ⪢ hexoestrol ⪢ 17 α-ethynyloestradiol ⪢ 4-hydroxytamoxifen ⪢ 17 β-oestradiol ⪢ tamoxifen. Compounds acting as antioxidants towards lipids may also exert pro-oxidant effects towards other molecules such as DNA and thus must never be assumed to be safe for human use.Keywords
This publication has 19 references indexed in Scilit:
- The structural mimicry of membrane sterols by tamoxifen: evidence from cholesterol coefficients and molecular-modelling for its action as a membrane anti-oxidant and an anti-cancer agentBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1992
- Overview From the International Conference on Long-Term Tamoxifen Therapy for Breast CancerJNCI Journal of the National Cancer Institute, 1992
- Results of the Cancer Research Campaign Adjuvant Trial for Perioperative Cyclophosphamide and Long-Term Tamoxifen in Early Breast Cancer Reported at the Tenth Year of Follow-UpActa Oncologica, 1992
- Drug Antioxidant EffectsDrugs, 1991
- Cellular effects of tamoxifen in primary breast cancerBreast Cancer Research and Treatment, 1991
- Mechanism of inhibition of lipid peroxidation by tamoxifen and 4‐hydroxytamoxifen introduced into liposomesFEBS Letters, 1990
- The antioxidant action of tamoxifen and its metabolites Inhibition of lipid peroxidationFEBS Letters, 1990
- Action of lead(II) and aluminium(III) ions on iron-stimulated lipid peroxidation in liposomes, erythrocytes and rat liver microsomal fractionsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1988
- Development of Cervical and Vaginal Squamous Cell Neoplasia As a Late Consequence of In Utero Exposure to DiethylstilbestrolObstetrical & Gynecological Survey, 1988
- Possible role of oxygen radicals in cell transformation by diethylstilbestrol and related compoundsCarcinogenesis: Integrative Cancer Research, 1986