Monilial Esophagitis in a Patient with Hemoglobin SC Disease

Publisher Website
Google Scholar
Abstract
A 22-year-old Negro female with asymptomatic hemoglobin sickle cell (SC) disease entered the Johns Hopkins Hospital with painful dysphagia of one day''s dura-tion. Esophagoscopy revealed a reddened, friable, edematous esophageal mucosa. Biopsy showed hyphae and yeast forms of Candida albicans invading the mucosa. Culture grew C. albicans. Reutine fluoroscopy with barium swallow revealed an irregular mucosa with a "moth -eaten" appearance. Segmental esophageal spasm coincident with paroxysms of pain was demonstrated with cine-radiofluorography. Monilial infection confined to the esophagus previously has been described only in association with diabetes mellitus, terminal malignancies, especially those invading the blood stream, or broad-spectrum antibiotic therapy. Monilial esophagitis has not been reported in association with the established hemoglobinopathies. Thus, this case is thought the first recognized example of monilial esophagitis occurring either as a primary disease or in association with hemoglobin SC disease.

This publication has 1 reference indexed in Scilit: