Clinical diagnosis of Down's syndrome
- 1 May 1976
- journal article
- research article
- Published by Wiley in Clinical Genetics
- Vol. 9 (5) , 483-487
- https://doi.org/10.1111/j.1399-0004.1976.tb01601.x
Abstract
A physical examination checklist of 25 signs of Down''s syndrome was used to predict the presence or absence of 21-trisomy in 291 individuals examined for suspected Down''s syndrome. Using only total numbers of signs present, 21-trisomy was predicted in about 1/2 those examined. Discriminant analysis using the most informative 10 signs misclassified only 11 of 169 infants aged 2 yr or less, and allowed non-overlapping classification into Down''s and non-Down''s of almost 3/4 of suspected individuals. The risk for Down''s syndrome in the overlap area was 58%.This publication has 9 references indexed in Scilit:
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