FURTHER STUDIES IN THE MECHANISM OF VASCULAR HYPERTENSION FOLLOWING THE INTRACISTERNAL INJECTION OF KAOLIN IN THE RAT

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Abstract
Following the intracisternal inj. of kaolin in the rat, vascular hypertension occurs by the 5th to 12th day but tends to fall to normal by the 3rd mo. There is increased cerebrospinal fluid pressure, and internal communicating hydrocephalus frequently, though not invariably, occurs in animals surviving a month or more. There is impairment of perineural absorption from the cerebrospinal space into the lymphatic system, but no alteration in absorption into the blood stream. There probably is block of the perivascular spaces leading to the surface of the cortex, which may be a factor in the production of the hydrocephalus. In longstanding cases the gray matter of the cortex is thinned, out of proportion to that seen in exptl. hydrocephalus due to cerebellar tumor. The water content of the brain is normal. Blood vol. is normal. Minute vessel pressure is increased but falls in the flare area of a burn. Mean pressure and systolic arterial pressure are both elevated. The hypertension can occur following complete bilateral adrenalec-tomy.

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