Vitamin D deficiency in early life accelerates Type 1 diabetes in non-obese diabetic mice
- 1 March 2004
- journal article
- research article
- Published by Springer Nature in Diabetologia
- Vol. 47 (3) , 451-462
- https://doi.org/10.1007/s00125-004-1329-3
Abstract
1,25-dihydroxyvitamin D3, the active form of vitamin D, prevents Type 1 diabetes in non-obese diabetic (NOD) mice. Epidemiological data show a threefold increase in human Type 1 diabetes when vitamin D deficiency was present in the first months of life. To evaluate whether a similar dietary deficiency affects diabetes incidence in NOD mice, we generated NOD mice with vitamin D deficiency in early life.Keywords
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