1α‐Hydroxyvitamin D3 inhibits Type II collagen‐induced arthritis in rats
- 17 January 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 337 (3) , 248-250
- https://doi.org/10.1016/0014-5793(94)80201-7
Abstract
The effects of 1α‐hydroxyvitamin D3 and 24,25‐dihydroxyvitamin D3 on Type II collagen‐induced arthritis in rats, an experimental model of rheumatoid arthritis, were examined. Oral administration of 1α‐hydroxyvitamin D3 significantly suppressed the incidence of arthritis and inhibited hind paw swelling. The level of anti‐Type II collagen antibodies was decreased in the 1α‐hydroxyvitamin D3 treated‐group. In contrast, 24,25‐dihydroxyvitamin D3, indomethacin, and gold had no effect on either the incidence of arthritis or the antibody levels. These findings demonstrate a beneficial effect of 1α‐hydroxyvitamin D3 on Type II collagen‐induced arthritis in rats and indicate that it has an antirheumatic effect.Keywords
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