QUATERNARY AMMONIUM-LINKED GLUCURONIDES OF AMITRIPTYLINE, IMIPRAMINE, AND CHLORPROMAZINE
- 1 January 1983
- journal article
- research article
- Vol. 11 (3) , 221-225
Abstract
The quaternary ammonium-linked glucuronides of amitriptyline, imipramine and chlorpromazine were conjugated in vitro using an immobilized rabbit hepatic microsomal enzyme preparation. Fast atom bombardment mass spectrometry could be used for direct characterization of these involatile, thermally labile metabolites. The quaternary ammonium-linked glucuronides of amitriptyline and imipramine were present in urine from patients receiving therapeutic doses of these tricyclic antidepressants.This publication has 8 references indexed in Scilit:
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