Antinuclear Antibody Induced by Procainamide

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Abstract
Sixteen patients were followed prospectively for the possible development of the lupus syndrome while being treated for cardiac arrhythmias with conventional doses of procainamide hydrochloride. In eight antinuclear antibody developed. Two of the eight had positive slide reactions with nucleoprotein-coated latex particles. In one of these two rheumatoid factor (anti-IgG) activity in low titer also developed. Another two of the eight showed symptoms consistent with the lupus syndrome.