Acrylamide: Induction of heritable translocations in male mice
- 1 January 1987
- journal article
- research article
- Published by Wiley in Environmental Mutagenesis
- Vol. 9 (4) , 363-368
- https://doi.org/10.1002/em.2860090403
Abstract
Acrylamide (AA), known to induce dominant lethals in male rodents, was studied in the mouse heritable translocation test by using intraperitoneal injections on 5 consecutive days. Matings on days 7-10 following the last injection yielded a high frequency of translocation carriers in the F1 male population, which demonstrated that acrylamide is an effective inducer of translocations in postmeiotic germ cells. As an inducer of both dominant lethals and heritable translocations in late spermatids and early spermatozoa, AA is similar to alkylating agents such as ethylmethanesulfonate and ethylene oxide. However, AA′s chemical structure, the nature of adducts formed with DNA, and its lack of mutagenicity in bacteria suggest a different mechanism as the basis for AA′s germ cell mutagenicity.Keywords
This publication has 18 references indexed in Scilit:
- Dominant lethal effects of subchronic acrylamide administration in the male Long-Evans ratMutation Research Letters, 1986
- Dominant lethal effects of acrylamide in male miceMutation Research Letters, 1986
- Distribution and binding of [14C]acrylamide to macromolecules in SENCAR and BALBc mice following oral and topical administrationToxicology and Applied Pharmacology, 1985
- Methylation of DNA and protamine by methyl methanesulfonate in the germ cells of male miceMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1983
- Carcinogen-mediated induction of SV40 DNA amplification is enhanced by acrylamide in Chinese hamster CO60 cellsCarcinogenesis: Integrative Cancer Research, 1983
- Comparison of two methods for detecting translocation heterozygotes in miceMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1981
- Mutagenicity of vinyl compounds in salmonella typhimuriumTeratogenesis, Carcinogenesis, and Mutagenesis, 1981
- A comparison of the molecular action of an SN1-type methylating agent, methyl nitrosourea and an SN2-type methylating agent, methyl methanesulfonate, in the germ cells of male miceChemico-Biological Interactions, 1981
- Ethylation pf DNA and protamine by ethyl methanesulfonate in the germ cells of male mice and the relevancy of these molecular targets to the induction of dominant lethalsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1978
- An Air-Drying Method for Meiotic Preparations from Mammalian TestesCytogenetic and Genome Research, 1964