Carcinogen-mediated induction of SV40 DNA amplification is enhanced by acrylamide in Chinese hamster CO60 cells
- 1 January 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 4 (11) , 1459-1463
- https://doi.org/10.1093/carcin/4.11.1459
Abstract
The incorporation of O6-methyl-dGTP during DNA replication in vitro by ‘Klenow’ E. coli pol I was determined. O6-Methyl-dGTP was found to: (i) incorporate opposite T and C template residues, with a > 20-fold preference for T, and (ii) arrest DNA synthesis when incorporated in place of dATP at all but pyrimidine-rich growing-strand sequences. The significance of O6-methyl-dGTP incorporation during DNA biosynthesis in vivo for mutagenesis and carcinogenesis is discussed.This publication has 4 references indexed in Scilit:
- RELATIONSHIP BETWEEN ABERRANT DNA-REPLICATION AND LOSS OF CELL VIABILITY IN CHINESE-HAMSTER OVARY CHO-K1-CELLS1982
- Carcinogen-mediated amplification of viral DNA sequences in simian virus 40-transformed Chinese hamster embryo cells.Proceedings of the National Academy of Sciences, 1981
- On the possibility of metabolic control of replicon "misfiring": relationship to emergence of malignant phenotypes in mammalian cell lineages.Proceedings of the National Academy of Sciences, 1981
- Carcinogen-mediated induction of SV40 DNA synthesis in SV40 transformed Chinese hamster embryo cellsCarcinogenesis: Integrative Cancer Research, 1981