Zur Biochemie der Oxalsäure. II. Ausscheidung und Retention injizierter 1.2-14C-Oxalsäure bei normalen, rachitischen und alloxandiabetischen Ratten

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Abstract
The excretion and retention of exogenic oxalic acid depends on the amount administered. Small amounts are largely eliminated in the urine in the course of 1 day while the kidney retains practically no oxalate. Larger doses are stored to a considerable extent in the kidney and approximately one third only appears in the urine. Repeated administration of small doses does not cause increased retention in the kidney. Rachitic rats respond to subcutaneous injection of medium doses of oxalate with an increased renal excretion as compared with normal control animals of the same weight or age. After 28 hours the bones of rachitic rats contain less oxalate than those of healthy animals. Widely divergent results were obtained in respect of the retention in the kidney so that is impossible to say whether rachitic and normal rats show any difference in this respect. Increased diuresis causes no significant change in the renal oxalate excretion. Alloxan-diabetic and healthy rats excrete oxalic acid doses to the same extent.

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