Antihypertensive Properties of Polythiazide and Chlorothiazide

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Abstract
Polythiazide, a new benzothiadiazine diuretic, was compared with chlorothiazide and with a placebo in a double-blind study of 19 ambulatory patients with mild-to-moderate arterial hypertension. The chlorothiazide was given twice daily in doses of 500 mg; the polythiazide (250 times as potent), twice daily in doses of 2 mg. With the dosages used, the average blood pressure was reduced significantly by both diuretics as compared with the placebo. Significant but asymptomatic decreases occurred in the concentrations of serum potassium and of plasma chlorides and in body weight, while statistically significant but slight increases occurred in pulse rate and in serum uric acid, urea, and carbon dioxide levels during treatment with polythiazide. Disturbing side effects from either polythiazide or chlorothiazide were infrequent and usually were manifested by postural dizziness in the more responsive patients.