Synthesis and biological activity of LH-RH analogs substituted by alkyltryptophans at position 3.
- 1 January 1979
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 27 (8) , 1907-1911
- https://doi.org/10.1248/cpb.27.1907
Abstract
Analogs (7) of luteinizing hormone-releasing hormone (LH-RH), in which the Trp residue at position 3 was replaced by various methyltryptophans and 1-ethyltryptophan, were synthesized and their LH-releasing activities were evaluated in rats. All of the analogs showed reduced hormonal activity compared with synthetic LH-RH.This publication has 1 reference indexed in Scilit:
- Analogues of luteinizing hormone-releasing hormone with modification in position 3.CHEMICAL & PHARMACEUTICAL BULLETIN, 1975