Effect of Corticoids on the Resistance of the Kidney to an Excess of Phosphates
- 30 September 1956
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 187 (1) , 41-44
- https://doi.org/10.1152/ajplegacy.1956.187.1.41
Abstract
In unilaterally nephrectomized rats, the substitution of 1.2% NaH2PO4 for drinking water rapidly produced marked calcium deposition in the pars intermedia of the kidney. This effect of the phosphate solution is enhanced by concurrent treatment with desoxycorticosterone acetate (DCA) and inhibited by cortisol acetate (COLA). The possible rôle of corticoids in the production of clinical nephrocalcinosis and renal calculus formation is briefly discussed.Keywords
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