Aurora-A — A guardian of poles
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- 1 January 2005
- journal article
- review article
- Published by Springer Nature in Nature Reviews Cancer
- Vol. 5 (1) , 42-50
- https://doi.org/10.1038/nrc1526
Abstract
The three human homologues of Aurora kinases (A, B and C) are essential for proper execution of various mitotic events and are important for maintaining genomic integrity. Aurora-A is mainly localized at spindle poles and the mitotic spindle during mitosis, where it regulates the functions of centrosomes, spindles and kinetochores required for proper mitotic progression. Recent studies have revealed that Aurora-A is frequently overexpressed in various cancer cells, indicating its involvement in tumorigenesis. What are the normal physiological roles of Aurora-A, how are these regulated and how might the enzyme function during tumorigenesis?Keywords
This publication has 89 references indexed in Scilit:
- Cancer genes and the pathways they controlNature Medicine, 2004
- STK15 polymorphism and breast cancer risk in a population-based studyCarcinogenesis: Integrative Cancer Research, 2004
- Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2–M transitionJournal of Cell Science, 2004
- Aurora-A and an Interacting Activator, the LIM Protein Ajuba, Are Required for Mitotic Commitment in Human CellsCell, 2003
- A Novel Mechanism for Activation of the Protein Kinase Aurora ACurrent Biology, 2003
- Functional Significance of the Specific Sites Phosphorylated in Desmin at Cleavage Furrow: Aurora-B May Phosphorylate and Regulate Type III Intermediate Filaments during Cytokinesis Coordinatedly with Rho-kinaseMolecular Biology of the Cell, 2003
- The LIM Protein Ajuba Is Recruited to Cadherin-dependent Cell Junctions through an Association with α-CateninJournal of Biological Chemistry, 2003
- Drosophila Aurora-A Is Required for Centrosome Maturation and Actin-Dependent Asymmetric Protein Localization during MitosisCurrent Biology, 2002
- The Xenopus laevis Aurora/Ip11p-Related Kinase pEg2 Participates in the Stability of the Bipolar Mitotic SpindleExperimental Cell Research, 2000
- A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancersThe EMBO Journal, 1998