Identification of a new member of the protegrin family by cDNA cloning

13 June 1994

journal article
research article
Published by Wiley in FEBS Letters

Vol. 346 (2-3) , 285-288
https://doi.org/10.1016/0014-5793(94)00493-5

Abstract

The porcine leukocyte protegrins are a family of cysteine‐rich antimicrobial peptides the primary structures of which combine features of defensins and tachyplesins. We cloned three protegrins from porcine bone marrow mRNA by PCR, including one (PG‐4) that was previously unknown. The 691 bp protegrin cDNAs were > 98.8% identical, and each was surrounded by highly conserved 5′ and (in some instances) 3′ sequences present in structurally dissimilar antimicrobial and LPS‐binding peptides of animal leukocytes.

Keywords

This publication has 21 references indexed in Scilit:

Pig leukocyte cysteine proteinase inhibitor (PLCPI), a new member of the stefin family
FEBS Letters, 1993
Molecular cloning of a putative homolog of proline/arginine‐rich antibacterial peptides from porcine bone marrow
FEBS Letters, 1993
A cDNA Derived from Pig Bone Marrow Cells Predicts a Sequence Identical to the Intestinal Antibacterial Peptide PR-39
Biochemical and Biophysical Research Communications, 1993
A Novel cDNA Sequence Encoding a Pig Leukocyte Antimicrobial Peptide with a Cathelin-like Pro-sequence
Biochemical and Biophysical Research Communications, 1993
Primary structure of three cationic peptides from porcine neutrophils
FEBS Letters, 1993
Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins
FEBS Letters, 1993
cDNA sequence analysis of an antibiotic dodecapeptide from neutrophils
FEBS Letters, 1992
CDNA cloning of the neutrophil bactericidal peptide indolicidin
Biochemical and Biophysical Research Communications, 1992
Complementary DNA sequence of rabbit CAP18—A unique lipopolysaccharide binding protein
Biochemical and Biophysical Research Communications, 1991
Primary structure of a new cysteine proteinase inhibitor from pig leucocytes
FEBS Letters, 1989