Intergeneric Cosynthesis of Penicillin by Strains of Penicillium chrysogenum, P. chrysogenum/notatum and Aspergillus nidulans

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Abstract
A number of mutants impaired in penicillin production were previously isolated from P. chrysogenum and A. nidulans. During cofermentation of osmotically fragile mycelia derived from these strains, in the presence of inhibitors of cell wall regeneration, intergeneric cosynthesis was demonstrated between mutants which are probably impaired in different parts of the penicillin biosynthetic pathway.