Fimoperon variation in the emergence of EnterohemorrhagicEscherichia coli: an evolutionary and functional analysis
Open Access
- 1 August 2007
- journal article
- research article
- Published by Oxford University Press (OUP) in FEMS Microbiology Letters
- Vol. 273 (1) , 58-63
- https://doi.org/10.1111/j.1574-6968.2007.00781.x
Abstract
Fim operons were examined to illuminate the emergence of Escherichia coli O157:H7 from the less-virulent E. coli O55:H7. A fim invertible element deletion occurred only after O157:H7 descended from O55:H7, and after sorbitol nonfermenting O157 diverged. Type 1 pili nonexpression correlates with this deletion in all enterohemorrhagic E. coli (EHEC) tested. An N135K FimH mutation in the two most evolved O157:H7 clusters is not found in other EHEC. These data refine the evolutionary history of an emerging pathogen.Keywords
This publication has 17 references indexed in Scilit:
- Molecular and phenotypic profiling of sorbitol-fermenting Escherichia coli O157:H− human isolates from FinlandClinical Microbiology & Infection, 2006
- Molecular Epidemiology of Extraintestinal PathogenicEscherichia coliEcoSal Plus, 2004
- The FimH A27V Mutation Is Pathoadaptive for Urovirulence in Escherichia coli B2 Phylogenetic Group IsolatesInfection and Immunity, 2003
- Shiga toxin-producing Escherichia coli in children with diarrhea: A prospective point-of-care studyThe Journal of Pediatrics, 2002
- Analysis of Urinary Escherichia coli Isolates for Ability To Produce Shiga ToxinJournal of Clinical Microbiology, 2002
- Structural basis of tropism of Escherichia coli to the bladder during urinary tract infectionMolecular Microbiology, 2002
- Type 1 Fimbriation and Its Phase Switching in Diarrheagenic Escherichia coli StrainsClinical and Diagnostic Laboratory Immunology, 2001
- Occurrence of verotoxin (Shiga-like toxin) producingEscherichia coli in human urinary tract infectionInfection, 1994
- P Fimbriae and Other Virulence Factors in Escherichia coli Urosepsis: Association with Patients' CharacteristicsThe Journal of Infectious Diseases, 1987
- An invertible element of DNA controls phase variation of type 1 fimbriae of Escherichia coli.Proceedings of the National Academy of Sciences, 1985