The FimH A27V Mutation Is Pathoadaptive for Urovirulence in Escherichia coli B2 Phylogenetic Group Isolates
Open Access
- 1 June 2003
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 71 (6) , 3619-3622
- https://doi.org/10.1128/iai.71.6.3619-3622.2003
Abstract
Correlations between FimH mutations and virulence were established by studying a collection of human commensal and extraintestinal pathogenic Escherichia coli natural isolates. Pathoadaptive (A27V and, to a lesser extent, A119V) and “commensal-adaptive” (A202V) mutations were evidenced in B2 phylogenetic group strains. fimH phylogenetic analysis indicates that these pathoadaptive mutations occurred several times.Keywords
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