SERUM IODINE FRACTIONS IN HYPERTHYROIDISM 12

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Abstract
Protein-bound iodine was separated from inorganic I in serum by precipitation with ZnSO4 and NaOH solns. of the concs. recommended by Somogyi for prep. of blood filtrates. I in the precipitate and filtrate was detd. by the permanganate acid ashing technique. When solns. of diiodo-tyrosine or thyroxin were added to serum the precipitate from serum contained at least 80% of diiodotyrosine I and virtually all thyroxin I. The precipitable I of 6 euthyroid subjects given 10-45 drops of Lugol''s soln. daily for 1-7 days agreed within 1.6 [gamma] % with serum total I after Lugol''s adm. was stopped. In euthyroid individuals after cessation of I adm., 2 days, but occasionally 4-10 days, were necessary for elimination of excess inorganic I from the serum. Precipitable I were studied in 15 hyperthyroid patients whose clinical diagnosis was confirmed by pathological study of the glands. Before treatment with I, serum total or precipitable I were between 9.4 and 33.7 [gamma] per 100 cc, distinctly above the normal range of 4-8 [gamma] %. In 5 patients, before adm. of I, total and precipitable I agreed within 2.0 [gamma] %. After Lugol''s, before thyroidectomy, precipitable I of 11 of 14 patients decreased to about 8.0 [gamma] %. In 3 patients, whose precipitable I did not decrease noticeably, clinical response to I adm. was poor. If basal metabolisms are unsatisfactory, the behavior of the precipitable I is of diagnostic significance. Serum total or precipitable I of 10 of 15 patients were within or just above the normal range about 2 wks. after thyroidectomy.

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