High resolution matrix‐assisted laser desorption/ionization time‐of‐flight analysis of single‐stranded DNA of 27 to 68 nucleotides in length

Abstract
Mass spectra of single-stranded DNA oligonucleotides were acquired using matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry (MALDI-TOFMS). Resolution enhancement using space–velocity correlation focusing allows for facile observation of different oligomers, the direct observation of individual DNA–metal adducts, and investigation of counter ion structure.