AUTOCRINE GROWTH OF INTERLEUKIN 2-PRODUCING LEUKEMIC-CELLS IN A PATIENT WITH ADULT T-CELL LEUKEMIA
- 1 September 1986
- journal article
- research article
- Vol. 68 (3) , 779-782
Abstract
Leukemic cells in the peripheral blood of a patient with adult T cell leukemia (ATL), which expressed the Tac antigen/interleukin 2 (IL 2) receptor, were investiated in vitro for autocrine growth by IL 2. The cells showed spontaneous proliferation in mitogen-free medium. The spontaneous proliferation of the cells was inhibited by monoclonal anti-IL2 or anti-Tac antibody. These cells were found to produce messenger RNA for IL 2 and secrete IL 2 during short-term culture in the same medium. Recombinant IL 2 and IL 2 secreted by the cells enhanced by proliferation of the cells in a dose-dependent manner when added to the autocrine mechanism by IL 2 is involved in the proliferation of ATL cells during short-term culture.This publication has 11 references indexed in Scilit:
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