Human Chorionic Gonadotrophin and Pregnancy-Specific Beta-1-Glycoprotein in Predicting Pregnancy Outcome and in Association with Early Pregnancy Vomiting

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Abstract
Serum concentrations of human chorionic gonadotrophin (HCG) and pregnancy-specific .beta.1-glycoprotein (SP1) were measured in 99 women between the 6th and 10th gestational wk, before the onset of pregnancy-threatening complications. The markers failed to predict threatening abortion appearing 9-112 days after sampling (n = 11), regardless of whether the pregnancy continued (n = 2) or ended with abortion (n = 9). Normal HCG and SP1 values were observed in 4 women who subsequently had preterm delivery. Women (14) with daily vomiting had higher mean serum concentrations of HCG (P < 0.01) and SP1 (P < 0.05) than 12 women of the same gestational duration without nausea or vomiting. Random single HCG or SP1 determinations have minimal clincal value in predicting the failure of pregnancy and that early pregnancy vomiting seems to be associated with raised serum HCG and SP1 concentrations.