One Factor Recognizes the Liver-Specific Enhancers in α 1 -Antitrypsin and Transthyretin Genes
- 12 February 1988
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 239 (4841) , 786-788
- https://doi.org/10.1126/science.3257586
Abstract
Four different regulatory sites required for transcriptional stimulation by the enhancers of two unrelated liver-specific genes α 1 -antitrypsin and transthyretin appear to bind the same nuclear protein that is found mainly in the liver. Such proteins may provide a basis for a coordinated, hepatocyte-specific control of gene transcription.Keywords
This publication has 22 references indexed in Scilit:
- Human Proto-Oncogene c- jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1Science, 1987
- Purified transcription factor AP-1 interacts with TPA-inducible enhancer elementsCell, 1987
- Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factorCell, 1987
- Factors that interact with the rat albumin promoter are present both in hepatocytes and other cell types.Genes & Development, 1987
- Transcriptional selectivity of viral genes in mammalian cellsCell, 1986
- Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box regionCell, 1985
- Transcriptional and post-transcriptional control of specific messenger RNAs in adult and embryonic liverJournal of Molecular Biology, 1984
- Structural and functional analysis of the human metallothionein-IA gene: Differential induction by metal ions and glucocorticoidsCell, 1984
- Transcriptional control in the production of liver-specific mRNAsCell, 1981
- Protein Inhibitors of ProteinasesAnnual Review of Biochemistry, 1980