19-HYDROXY-Δ4-ANDROSTENE-3,17-DIONE AN INTERMEDIATE IN ESTROGEN BIOSYNTHESIS1
- 1 March 1960
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 66 (3) , 416-419
- https://doi.org/10.1210/endo-66-3-416
Abstract
Incubation of Δ4-androstene-3,17-dione-4-C14 with a human placental preparation yielded 19-hydroxy-Δ4-androstene-3,17-C14 in addition to estrone-C14. The 19-hydroxy steroid had previously been shown to be converted in good yield to estrone. This is the first direct demonstration of 19-hydroxylase in a tissue other than adrenal and more firmly establishes the 19-hydroxy derivative as an intermediate in the biosynthesis of estrogens from androgens.Keywords
This publication has 5 references indexed in Scilit:
- Biological Aromatization of SteroidsJournal of Biological Chemistry, 1959
- CONVERSION OF TESTOSTERONE TO ESTROGENS IN CASTRATED, ADRENALECTOMIZED HUMAN FEMALESJournal of Biological Chemistry, 1956
- CONVERSION OF TESTOSTERONE-3-C-14 TO C-14-ESTRADIOL-17 BETA BY HUMAN OVARIAN TISSUE1956
- BIOGENESIS OF THE ESTROGENS: THE CONVERSION OF TESTOSTERONE-4-C14TO ESTRONE IN THE PREGNANT MARE1Endocrinology, 1955
- Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissuesBiochemical Journal, 1952