SYSTEMIC AND CORONARY HEMODYNAMIC EFFECTS OF ERYTHROL TETRANITRATE*

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Abstract
The coronary and systemic hemodynamic effects of sublingual administration of erythrol tetranitrate in human subjects have been investigated by the nitrous oxide and Fick principles respectively. The study revealed that the drug appeared to act by decreasing central venous, pulmonary arterial and systemic arterial blood pressures. Cardiac output was reduced and cardiac work decreased. Coronary blood flow and left ventricular myocardial oxygen consumption were unchanged. The coronary sinus oxygen content did not change. Since coronary blood flow was unchanged at a reduced arterial pressure, coronary vascular resistance was calculated to be reduced.