REPRODUCIBILITY OF CO2 RESPONSE CURVES WITH 10 MINUTES SEPARATING EACH REBREATHING TEST

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Abstract
It is unclear if duration of the interval separating CO2 rebreathing tests has any effect on the CO2 response curve. In normal [human] subjects, slopes and intercepts, respectively, of CO2 response curves from 3 rebreathing tests separated by each of 3 different time intervals (10, 20 and 30 min) were compared. Slopes and intercepts, respectively, were no different from the 1st through 3rd test with each interval, and no difference between tests from different intervals. Reproducibility of slope and intercept was not affected by the time interval separating each test. During each rebreathing test, heart rate and systolic blood pressure increased but diastolic blood pressure decreased. These effects resolved within 10 min after the test. In normal subjects, 3 CO2 rebreathing tests can be repeated rapidly with only 10 min of rest separating each test.