A Requirement for Two Cell Types for Antibody Formation in vitro
- 22 December 1967
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 158 (3808) , 1573-1575
- https://doi.org/10.1126/science.158.3808.1573
Abstract
A suspension of mouse spleen cells can be separated into two populations on the basis of their ability or inability to adhere to plastic dishes. It was found that both adherent and nonadherent cells were necessary for the induction of antibody formation to sheep red blood cells in vitro. Exposure of adherent cells to antigen for brief periods of time was sufficient to initiate a maximal in vitro response.This publication has 13 references indexed in Scilit:
- IMMUNIZATION OF DISSOCIATED SPLEEN CELL CULTURES FROM NORMAL MICEThe Journal of Experimental Medicine, 1967
- Immunization of Normal Mouse Spleen Cell Suspensions in vitroScience, 1966
- Induction in vitro of Antibodies to Phage T2: Antigens in the RNA Extract EmployedScience, 1965
- Immunogenicity of Antigen-Containing Ribonucleic Acid Preparations from MacrophagesNature, 1965
- Antibody Production by Nonimmune Spleen Cells Incubated with RNA from Immunized MiceScience, 1964
- In Vitro Transfer of Macrophage RNA to Lymph Node CellsNature, 1963
- ANTIBODY FORMATION INITIATED IN VITROThe Journal of Experimental Medicine, 1963
- INTRACELLULAR LOCALIZATION AND QUANTITATION OF TRITIATED ANTIGENS IN RETICULOENDOTHELIAL TISSUES OF MICE DURING SECONDARY AND HYPERIMMUNE RESPONSESThe Journal of Experimental Medicine, 1962
- Immunogenic Sub-Cellular Particles Obtained from Spleens of Antigen-Injected MiceNature, 1962
- Antibody Formation in Tissue CultureNature, 1959