Distribution of Cystatin C (γ-Trace), an Inhibitor of Lysosomal Cysteine Proteinases, in the Anterior Lobe of Simian and Human Pituitary Glands

Abstract
Cystatin C, a protein inhibitor of lysosomal cysteine proteinases, was demonstrated by immunohistochemical techniques to be present in most luteinizing hormone- (LH-)containing cells in simian and human adenohypophyses. Immunoreactivity of cystatin C was also found in simian adrenocorticotrophic hormone- (ATCH-)containing cells localized to an area corresponding to the pars intermedia but not in the ACTH-containing cells of the anterior pituitary lobe of monkey. No immunoreactivity of cystatin C was detected in the growth hormone-(GH-) and prolactin-containing cells of monkey and man.

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