Evolution of Immunoglobulin Polypeptide Chains: Carboxy-Terminal of an IgM Heavy Chain
- 23 December 1966
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 154 (3756) , 1561-1562
- https://doi.org/10.1126/science.154.3756.1561
Abstract
The dipeptide sequence at the carboxy-terminal of a heavy (µ) chain from a human macroglobulin ( IgM) is tyrosylcysteine, although the reverse sequence, cysteinyltyrosine, has not been rigorously excluded. The presence of cysteine at the carboxy-terminal was predicted from a recognition of the chemical homologies among the polypeptide chains of immunoglobulins, and their probable evolutionary origin.Keywords
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