Experimental Herpes Simplex Encephalitis

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Abstract
An experimentally induced herpes simplex virus encephalitis in rabbits was treated with either idoxuridine or cytarabine. The cerebral lesions produced in this model bore histologic and topographic similarities to those seen in humans. Treatment was begun after infection was established in nervous system tissue. In animals treated with idoxuridine there was neither clinical nor histological evidence of a therapeutic effect. Cytarabine initially appeared to inhibit the development of lesions, but the effect was temporary.