Extrapituitary Action of Gonadotropin-Releasing Hormone: Direct Inhibition Ovarian Steroidogenesis
- 25 May 1979
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 204 (4395) , 854-855
- https://doi.org/10.1126/science.375393
Abstract
Gonadotropin-releasing hormone (GnRH) and its agonistic analogs inhibited the follicle-stimulating hormone (FSH)-induced increase of estrogen and progesterone production in vitro by rat ovarian granulosa cells. Likewise, GnRH analogs inhibited FSH-induced changes in ovarian function in hypophysectomized rats in vivo. These results indicate that GnRH, in addition to its well-known gonadotropin-releasing action in the pituitary, exerts a direct inhibition of ovarian steroidogenesis.This publication has 15 references indexed in Scilit:
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