A dopaminergic neurotoxin, (R)‐N‐methylsalsolinol, increases in parkinsonian cerebrospinal fluid
- 1 July 1996
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 40 (1) , 119-122
- https://doi.org/10.1002/ana.410400120
Abstract
The concentration of (R)‐N‐methylsalsolinol, which is a dopamine‐derived neurotoxin selective to dopamine neurons and induces parkinsonism in rats, was found to be increased significantly in the cerebrospinal fluid of untreated patients with Parkinson's disease. The enantiospecific occurrence of (R)‐N‐methylsalsolinol in cerebrospinal fluid suggests its enzymatic synthesis in the human brain. The individual differences in the activities of the enzymes determining the metabolism of (R)‐N‐methylsalsolinol in the brain might be involved in the pathogenesis of Parkinson's disease.Keywords
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