HYPERSENSITIVITY TO INSULIN IN EVISCERATED HYPOPHYSECTOMIZED RATS

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Abstract
The sensitivity to intravenously administered insulin was detd. in eviscerated normal and hypophysectomized rats. Blood glucose was detd. at the time of admn. of insulin and 20 mins. later. Under these conditions, the effect of the insulin was to accelerate the spontaneously occurring hypoglycemia. The minimum effective dose of insulin in the eviscerated normal rat was between 0.04 and 0.08 units/kg. as compared with 0.005 units/kg. in the hypophysectomized rat. Pre-treatment with crude ant. pituitary extract reduced the effectiveness of insulin in the eviscerated normal rat. It was concluded that the hypersensitivity to insulin observed in hypophysectomized rats is in part, an extra hepatic phenomenon.