The effect of fructose on the glucose tolerance curve

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Abstract
Fructose, when injected intraven., lowers the glucose tolerance curve of normal dogs, and also the glucose tolerance curve of depancreatized dogs receiving a steady supply of insulin. This effect in normal animals is evidently not due to a stimulation of the pancreas to give increased secretion of insulin. An hypothesis is advanced that fructose exerts a catalytic influence on the utilization of glucose, the site of this influence, probably, being in the glycogenesis mechanism of the liver.