Association analysis of a polymorphism of the monoamine oxidase B gene with Parkinson's disease in a Japanese population

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Abstract
The polymorphic allele of the monoamine oxidase B (MAO‐B) gene detected by polymerase chain reaction (PCR) and single‐stranded conformation polymorphism (SSCP) was associated with Parkinson's disease (PD) in Caucasians. We characterized this polymorphic allele, allele 1, of the MAO‐B gene using direct sequencing of PCR products. A single DNA substitution (G‐A), resulting gain of Mae III restriction site was detected in intron 13 of the MAO‐B gene. The allele associated with PD in Caucasians was twice as frequent as in healthy Japanese, but the association of the allele of the MAO‐B gene was not observed in Japanese patients with PD.